Epigenetic Alterations in Oncogenesis

Epigenetic Alterations in Oncogenesis

Author: Adam R. Karpf

Publisher: Springer Science & Business Media

ISBN: 9781441999672

Category: Medical

Page: 348

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The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.
Epigenetic Alterations in Oncogenesis
Language: en
Pages: 348
Authors: Adam R. Karpf
Categories: Medical
Type: BOOK - Published: 2012-09-06 - Publisher: Springer Science & Business Media

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known
Epigenetic Alterations in Oncogenesis
Language: en
Pages: 348
Authors: Adam R. Karpf
Categories: Medical
Type: BOOK - Published: 2012-09-06 - Publisher: Springer

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known
Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell
Language: en
Pages: 79
Authors: Yoshimasa Saito
Categories: Biology (General)
Type: BOOK - Published: 2014-11-10 - Publisher: Frontiers E-books

Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine
Investigation of Hallmark Epigenetic Changes in a Cancer Stem Cell Model
Language: en
Pages:
Authors: L. Wild
Categories: Biology (General)
Type: BOOK - Published: 2010 - Publisher:

Epigenetic control of gene expression is vital for normal development and differentiation of cells, and is also important in the development of disease. In particular, there is a strong association between hallmark epigenetic changes and cancer - namely, genome wide hypomethylation, gene specific hypermethylation and characteristic histone modification. Almost all
Epigenetic Advancements in Cancer
Language: en
Pages: 246
Authors: Manoj K. Mishra, Kumar S. Bishnupuri
Categories: Medical
Type: BOOK - Published: 2016-05-04 - Publisher: Springer

This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and